Effect of intraoperative fluid type on postoperative systemic inflammatory response and end organ dysfunction following total pancreatectomy with islet autotransplantation in children
| Autor: | Gillian R. Goddard, Monica L. Wagner, Todd M. Jenkins, Tom K. Lin, Jaimie D. Nathan, Maisam Abu-El-Haija, Stuart L. Goldstein |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Multiple Organ Failure Transplantation Autologous symbols.namesake Pancreatectomy Postoperative Complications medicine Humans Poisson regression Child Saline geography geography.geographical_feature_category business.industry Organ dysfunction Acute kidney injury General Medicine Acute Kidney Injury medicine.disease Islet Autotransplantation Systemic Inflammatory Response Syndrome Systemic inflammatory response syndrome Anesthesia Pediatrics Perinatology and Child Health symbols Fluid type Surgery Female medicine.symptom business |
| Zdroj: | Journal of pediatric surgery. 57(8) |
| ISSN: | 1531-5037 |
| Popis: | To evaluate the effect of intraoperative fluid type [half normal saline (0.45NS) or lactated Ringer's solution (LR)] on the risk of systemic inflammatory response syndrome (SIRS) and acute kidney injury after total pancreatectomy with islet autotransplantation in children.Retrospective review where demographics, operative details, systemic inflammatory response, and evaluation for end organ dysfunction over the first 5 postoperative days was obtained. Mixed effects Poisson regression compared risk of SIRS and acute kidney injury by intraoperative fluid type.Forty three patients were included with no difference in demographic characteristics between groups. SIRS was observed in 95, 77, and 71% over post operative days 1, 3, and 5. Intraoperative fluid type was found to not be associated with postoperative SIRS (RR: 0.91, p = 0.23). However, female sex (RR: 1.30, p 0.01), increased BMI (RR: 1.08, p 0.01), and longer operative time (RR: 1.07, p 0.01) were found to be factors that are associated with increased risk of postoperative SIRS. Intraoperative 0.45NS use was associated with increased acute kidney injury compared to LR on postoperative day 1 (52% vs 0%, p 0.01), but not on postoperative days 3 or 5.Intraoperative fluid type (0.45NS vs LR) does not increase the risk of postoperative SIRS in children after TPIAT. Predictive factors that are associated with an increased risk of eliciting postoperative SIRS includes female sex, increased BMI, and longer operative times.III. |
| Databáze: | OpenAIRE |
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