Cryptogenic small‐fiber neuropathies: Serum autoantibody binding to trisulfated heparan disaccharide and fibroblast growth factor receptor‐3
| Autor: | Jafar Kafaie, Alan Pestronk, Ruth Bland, David Saperstein, Todd Levine, Lawrence A. Zeidman, Reyanna Massaquoi |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Physiology Small Fiber Neuropathy 030105 genetics & heredity Fibroblast growth factor Immunoglobulin G Pathogenesis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Physiology (medical) Humans Receptor Fibroblast Growth Factor Type 3 Medicine Autoantibodies biology business.industry Autoantibody Fibroblast growth factor receptor 3 medicine.disease Immunoglobulin M Immunology biology.protein Female Neurology (clinical) Immune disorder Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Muscle & Nerve. 61:512-515 |
| ISSN: | 1097-4598 0148-639X |
| Popis: | Introduction Causes of small-fiber peripheral neuropathies (SFN) are often undefined. In this study we investigated associations of serum autoantibodies, immunoglobulin G (IgG) vs fibroblast growth factor receptor-3 (FGFR-3), and immunoglobulin M (IgM) vs trisulfated heparan disaccharide (TS-HDS) in cryptogenic SFN. Methods One hundred fifty-five patients with biopsy-proven SFN and no identified cause for their neuropathy were blindly tested for serum IgM vs TS-HDS and IgG vs FGFR-3. Results Forty-eight percent of SFN patients had serum antibodies, 37% with IgM vs TS-HDS and 15% with IgG vs FGFR-3. TS-HDS antibodies were more frequent in SFN patients than in controls (P = .0012). Both antibodies were more common in females, and with non-length-dependent nerve pathology. Nintey-two percent of patients with acute-onset SFN had serum IgM vs TS-HDS. Discussion Autoantibodies directed against TS-HDS and FGFR-3 suggest an immune disorder in otherwise idiopathic SFN. Serum IgM vs TS-HDS may be a marker for SFN with an acute onset. |
| Databáze: | OpenAIRE |
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