An Experimental Study of the Effect of Diindolylmethane on Alveolocyte and Hepatocyte Adhesion Strength in Mice
| Autor: | O. I. Pchelintseva, Igor Kuznetsov, V. V. Udut, Gennady T. Sukhikh, Vsevolod Kiselev, Vadim Drukh |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Indoles Chemistry medicine.medical_treatment Diindolylmethane General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Adhesion strength Pulmonary Alveoli 03 medical and health sciences Mice 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Hepatocyte medicine Hepatocytes Cba mice Animals Saline 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 168(1) |
| ISSN: | 1573-8221 |
| Popis: | We studied the effect of diindolylmethane in a dose of 600 mg/kg on the change in adhesion strength of alveolocytes and hepatocytes in CBA mice. Diindolylmethane was administered intragastrically to experimental animals for 10 days, controls intragastrically received an equivalent volume of saline. At the end of the therapeutic period, mice treated with diindolylmethane showed a significant increase in the adhesion strength of alveolocytes by 16% (p=0.003) and hepatocytes by 61% (p=0.0001) in comparison with the control group, which indicates the antipromotor activity of diindolylmethane. |
| Databáze: | OpenAIRE |
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