Healthcare utilization and financial impact of acute-graft-versus host disease among children undergoing allogeneic hematopoietic cell transplantation
| Autor: | Larisa Broglie, Diane George, Prakash Satwani, James Garvin, Angela Ricci, Matthew Hall, Zhezhen Jin, Monica Bhatia |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Graft vs Host Disease Single Center Cohort Studies 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Internal medicine Acute graft versus host disease Humans Medicine Risk factor Child Retrospective Studies Transplantation integumentary system Hematopoietic cell business.industry Incidence (epidemiology) Hematopoietic Stem Cell Transplantation Hematology surgical procedures operative Healthcare utilization 030220 oncology & carcinogenesis Acute Disease business Delivery of Health Care 030215 immunology Cohort study |
| Zdroj: | Bone Marrow Transplantation. 55:384-392 |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | The impact of AGVHD on healthcare utilization and cost is not well described. In this retrospective single center cohort study of 240 pediatric patients, we analyzed cost, healthcare utilization and patient outcomes for the first year post-alloHCT. Costs were estimated from charges recorded in the Pediatric Health Information System database and the hospital’s accounting system. The overall incidence of grade I–IV aGVHD was 40.4%. The incidence of grade I, grade II, and grade III–IV aGVHD was 6.6%, 16.2%, and 17.5%, respectively. The overall incidence of steroid refractory (SR)-aGVHD was 10.8%. The median number of days of hospitalization in the first year post-alloHCT was significantly higher for patients with aGVHD vs. no aGVHD: 113 days (range: 35–354 days) vs. 63 days (range: 25–298 days), p |
| Databáze: | OpenAIRE |
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