Synthesis and characterization of metformin-pluronic based polyurethanes for controlled drug delivery

Autor:	Efrén Hernández-Baltazar, R.F. Vargas-Coronado, Rocio Borges-Argaez, Jorge Froylan Xool-Tamayo, Marcos Bonilla-Hernández, Guido Antonio Zapata-Catzin, José M. Cervantes-Uc, Juan V. Cauich-Rodríguez, Omar de Jesús Castillo-Cruz
Rok vydání:	2020
Předmět:	Polymers and Plastics Biocompatibility Chemistry General Chemical Engineering Drug delivery medicine Soft segment Poloxamer Analytical Chemistry Metformin medicine.drug Segmented polyurethane Biomedical engineering
Zdroj:	International Journal of Polymeric Materials and Polymeric Biomaterials. 70:656-667
ISSN:	1563-535X 0091-4037
DOI:	10.1080/00914037.2020.1740996
Popis:	Segmented polyurethanes (SPU) were synthesized with Pluronic F127 (PLU) as soft segment and 4,4′-methylene-bis(cyclohexyl) diisocyanate (HMDI) and Metformin (Met) as rigid segment (HMDI-Met) while antidiabetic content increased by using 20%, 30%, 40%, and 50% of rigid segments. The Met incorporation was provided by FTIR, Raman, NMR, and XPS. By increasing the content of rigid segments, the first decomposition temperature tends to increase from 317 °C to 361 °C while Tg was modified from −80 °C to −50 °C. Mass loss was observed during accelerated degradation and therefore SPU-PLU-Met can deliver up to 40 µg/30 days of Met. Cytotoxicity test showed no deleterious effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580f451b7fa30d4dc1199d2b9276fb8b https://doi.org/10.1080/00914037.2020.1740996 Zobrazit plný text záznamu