Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: a pilot study
| Autor: | Giovanni Spera, G. M. C. Rosano, Roberto Bruzziches, Emanuela A. Greco, M Pili, Antonio Aversa |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Phosphodiesterase Inhibitors Urology Vascular Cell Adhesion Molecule-1 Pilot Projects Vasodilation Tadalafil Erectile Dysfunction Internal medicine medicine Humans Insulin Cross-Over Studies Endothelin-1 business.industry Middle Aged Intercellular Adhesion Molecule-1 medicine.disease Crossover study Discontinuation C-Reactive Protein Carotid Arteries Treatment Outcome medicine.anatomical_structure Endocrinology Blood pressure Erectile dysfunction cGMP-specific phosphodiesterase type 5 Endothelium Vascular business Biomarkers Carbolines Penis medicine.drug |
| Zdroj: | International Journal of Impotence Research. 19:200-207 |
| ISSN: | 1476-5489 0955-9930 |
| DOI: | 10.1038/sj.ijir.3901513 |
| Popis: | Men with erectile dysfunction (ED) frequently have a disproportionate burden of comorbid vascular disorders including atherosclerotic disease. We investigated whether scheduled tadalafil is better than on-demand (OD) in improving endothelium-dependent vasodilatation of cavernous arteries in men with ED and whether this effect is also exerted on markers of endothelial function. We did an open-label, randomized, crossover study including 20 male outclinic patients aged 18 years or older (mean age 54 years) who had at least a 3-month history of ED of any severity or etiology. Tadalafil (20 mg) on alternate days (ADs) or OD was administered for 4 weeks. Primary end points were variations of basal inflow (peak systolic velocity (PSV)) and flow-mediated dilatation (FMD) of cavernous arteries compared with baseline at penile Duplex ultrasound. Secondary end points were variations of Q13-SIEDY scores regarding morning erections and of markers of endothelial function, that is, vascular cell adhesion molecule (VCAM), intercellular cell adhesion molecule, endothelin-1 (ET-1), insulin and C-reactive protein (CRP). PSVs and FMD were higher after AD treatment when compared with OD and baseline, respectively (P=0.0001), and improvements were maintained from 2 weeks after discontinuation (P |
| Databáze: | OpenAIRE |
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