Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
Autor: | Hyunmin Chung, Ji-Yoon Noh, Haiyoung Jung |
---|---|
Rok vydání: | 2021 |
Předmět: |
Combination therapy
QH301-705.5 medicine.medical_treatment T-Lymphocytes CAR-T cell Cell Receptors Antigen T-Cell Review Immunotherapy Adoptive Catalysis Targeted therapy combination therapy Inorganic Chemistry Cell therapy Cancer immunotherapy medicine Humans Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Multiple myeloma business.industry Organic Chemistry General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Chimeric antigen receptor Computer Science Applications Chemistry medicine.anatomical_structure Cancer research challenge solid tumor Immunotherapy Lymphoma Large B-Cell Diffuse business Multiple Myeloma Diffuse large B-cell lymphoma |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 12126, p 12126 (2021) |
ISSN: | 1422-0067 |
Popis: | Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has shown remarkable results, with five US Food and Drug Administration (FDA) approvals to date. CAR-T cells have been very effective in hematologic malignancies, such as diffuse large B cell lymphoma (DLBCL), B cell acute lymphoblastic leukemia (B-ALL), and multiple myeloma (MM); however, its effectiveness in treating solid tumors has not been evaluated clearly. Therefore, many studies and clinical investigations are emerging to improve the CAR-T cell efficacy in solid tumors. The novel therapeutic approaches include modifying CARs in multiple ways or developing a combination therapy with immune checkpoint inhibitors and chemotherapies. In this review, we focus on the challenges and recent advancements in CAR-T cell therapy for solid tumors. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |
načítá se...