Alteration of Insulin-Binding Receptors in Non-Insulin Dependent Diabetes of the Young
| Autor: | L. Kautzky, Halmos T, Orosz A, Korányi L |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Monocytes Blood cell Endocrinology Diabetes mellitus Internal medicine Internal Medicine medicine Humans Receptor Pancreatic hormone Monocyte Insulin General Medicine Metabolism medicine.disease Receptor Insulin Red blood cell medicine.anatomical_structure Diabetes Mellitus Type 2 Female |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 91:183-190 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | The behaviour of insulin binding receptors is rather unelucidated in non-insulin-dependent diabetes mellitus of the young. Authors in continuing their previous work studied the behaviour of insulin binding receptors of erythrocytes and monocytes in 9 MODY patients. They observed that specific insulin binding of circulating blood cells was significantly decreased in all cases as compared to the controls despite of a good state of metabolism (in the case of erythrocytes 4.63 +/- 1.1% vs. 6.03 +/- 1.7%, p less than 0.05, in the case of monocytes 2.3 +/- 1.2% vs. 3.6 +/- 1.4%, p less than 0.05). The lower value of insulin binding resulted from the decrease of receptor concentrations (in the case of erythrocytes 2.36 +/- 0.78 pmol/l vs. 3.81 +/- 1.14 pmol/l, p less than 0.05). |
| Databáze: | OpenAIRE |
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