A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis
| Autor: | Masayo Maeda, Mikio Tanino, Yoshiaki Tsukio, Naomi Ueda, Shigeyuki Sugie, Hideki Mori, Hiroyuki Kohno, Keiji Wada, Takuji Tanaka |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Time Factors Colon Azoxymethane Antineoplastic Agents Crude drug Pharmacology Furanolactone Lactones chemistry.chemical_compound Basal (phylogenetics) Polyamines medicine Animals Radix Cell Nucleus Mucous Membrane Dose-Response Relationship Drug Terpenes business.industry Organ Size Rats Inbred F344 Terpenoid Rats Colon carcinogenesis Oncology chemistry Colonic Neoplasms Carcinogens Diterpenes Polyamine business |
| Zdroj: | Cancer Letters. 183:131-139 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(02)00159-3 |
| Popis: | The modifying effect of dietary administration of a diterpenoid furanolactone columbin isolated from the crude drug Calumbae Radix (the root of Jateorhiza columba MIERS, Menispermacea) on azoxymethane (AOM)-induced was investigated in male F344 rats. Animals were initiated with AOM (three weekly subcutaneous injections of 15 mg/kg body weight) to induce colonic neoplasms. They were fed the experimental diets mixed with columbin (4, 20, and 100 ppm) for 4 weeks, starting 1 week before the first dosing of AOM and thereafter maintained on the basal diet without columbin. Additional experimental groups included the AOM alone group, the columbin alone group (100 ppm in diet for 4 weeks), and the untreated control group. Dietary feeding of columbin (4, 20, and 100 ppm) during the initiation phase of AOM-induced colon carcinogenesis reduced the incidence and multiplicity of colonic adenocarcinoma and the inhibition by feeding of 20 ppm (incidence: 20%, P=0.0242 and multiplicity: 0.20+/-0.40, P |
| Databáze: | OpenAIRE |
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