Antitumor Agents, 138. Rotenoids and Isoflavones as Cytotoxic Constituents from Amorpha fruticosa
| Autor: | James R. Estes, Andrew T. McPhail, Takao Konoshima, Mutsuo Kozuka, Donald R. McPhail, Hiroki Terada, Leping Li, Kuo Hsiung Lee, Hui-Kang Wang, Jerjang Chang, Midori Kokumai |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Stereochemistry
Flavonoid Pharmaceutical Science Pharmacognosy Rotenoid Analytical Chemistry chemistry.chemical_compound Rotenone Drug Discovery Tumor Cells Cultured Humans Laryngeal Neoplasms Pharmacology chemistry.chemical_classification Plants Medicinal Natural product biology Organic Chemistry Tephrosin Isoflavones biology.organism_classification Antineoplastic Agents Phytogenic Complementary and alternative medicine chemistry Amorpha fruticosa Carcinoma Squamous Cell Molecular Medicine Neoplastic cell Drug Screening Assays Antitumor |
| Zdroj: | Journal of Natural Products. 56:690-698 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50095a005 |
| Popis: | Eight cytotoxic compounds have been isolated from the CHCl3 extract of Amorpha fruticosa. One compound, 6'-O-D-beta-glucopyranosyldalpanol [10], is a new cytotoxic rotenoid. Another known rotenoid, 12 alpha beta-hydroxyamorphigenin [6], was first shown to exhibit extremely potent cytotoxicity (ED50 < 0.001 microgram/ml) in six neoplastic cell lines. In addition to these compounds, three isoflavones (afrormosin [1], 7,2',4', 5'-tetramethoxyisoflavone [2], 8-methylretusin [3]) and five rotenoids (amorphispironone [4], amorphigenin [5], dalpanol [7], 12a beta-hydroxydalpanol [8], and tephrosin [9]) were isolated. Compound 8 was isolated for the first time as a natural product from this plant. The structures of these compounds were established on the basis of spectral data; some were further confirmed by X-ray crystallographic analysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|