Imaging the electro-kinetic response of biological tissues with optical coherence tomography
| Autor: | Vladislav Toronov, Valentin Demidov, Barry Vuong, Cuiru Sun, Victor X. D. Yang, Mark K. Harduar, Yuan Xu, Ozkan Doganay, Krzysztof Wawrzyn |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
genetic structures Swine Color 01 natural sciences Signal 010309 optics symbols.namesake Optics Electricity Optical coherence tomography Electric field 0103 physical sciences Digital image processing Image Processing Computer-Assisted medicine Animals 010301 acoustics medicine.diagnostic_test business.industry Myocardium Resolution (electron density) Soft tissue eye diseases Atomic and Molecular Physics and Optics Kinetics Fourier transform Amplitude symbols sense organs business Algorithms Tomography Optical Coherence |
| Zdroj: | Optics Letters. 38:2572 |
| ISSN: | 1539-4794 0146-9592 |
| DOI: | 10.1364/ol.38.002572 |
| Popis: | We demonstrate the feasibility of using optical coherence tomography (OCT) to detect and image an electro-kinetic response: electric-field induced optical changes (EIOC) in soft biological tissues. A low-frequency electric field was applied to ex vivo samples of porcine heart tissues, while OCT signals were acquired continuously. Experimental results show that the amplitude of the OCT signal change is proportional to the amplitude and inversely proportional to the frequency of the applied electric field. We show that the nonconductive component of the sample was eliminated in the normalized EIOC image. To the best our knowledge, this is the first time a two-dimensional image related to the electro-kinetic response of soft tissues is obtained with depth resolution. Since electro-kinetic properties can change during cancerogenesis, EIOC imaging can potentially be used for cancer detection. |
| Databáze: | OpenAIRE |
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