Prevalence of polycystic ovary syndrome in Chinese obese women of reproductive age with or without metabolic syndrome
| Autor: | Juan Shi, Wanyu Li, Yuying Deng, Lihui Yuan, Rui Wang, Weiqiong Gu, Jie Hong, Peiwen Liang, Weiqing Wang, Shaoqian Zhao, Liuqing Xi, Bin Gu, Yifei Zhang, Yingkai Sun |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty China Cross-sectional study 030209 endocrinology & metabolism Tertiary Care Centers 03 medical and health sciences Young Adult 0302 clinical medicine Insulin resistance Asian People Risk Factors Internal medicine medicine Prevalence Humans Obesity Adiposity Ultrasonography Metabolic Syndrome Glucose tolerance test Obesity Metabolically Benign 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Confounding Age Factors Obstetrics and Gynecology Glucose Tolerance Test medicine.disease Polycystic ovary Endocrinology Cross-Sectional Studies Reproductive Health Reproductive Medicine Female Metabolic syndrome Insulin Resistance business Tomography X-Ray Computed Body mass index Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | Fertility and sterility. 107(4) |
| ISSN: | 1556-5653 |
| Popis: | Objective To compare the prevalence of polycystic ovary syndrome (PCOS) and related clinical characteristics between metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) women of reproductive age. Design Cross-sectional clinical study. Setting Tertiary hospital. Patient(s) We studied 299 MUO and 122 MHO Chinese women matched on body mass index. Metabolically healthy obese was defined as obesity with no more than one metabolic abnormality. Diagnosis of PCOS was based on the revised Rotterdam criteria. Intervention(s) Each subject underwent physical examination, laboratory evaluation, and gynecologic ultrasound for a diagnosis of PCOS or metabolic syndrome (MetS). Main Outcome Measure(s) Prevalence of PCOS was calculated in both groups. Insulin resistance was determined by homeostasis model assessment of insulin resistance or by the insulin sensitivity index derived from Bergman's minimal model. Fat distribution was measured with computerized tomography scan. Result(s) Prevalence of PCOS and its components did not differ between MUO and BMI-matched MHO groups (67.89% and 66.96%, respectively). In logistic regression analysis, MetS did not predict the presence of PCOS after adjusting for confounding factors. The MHO group had lower visceral adipose tissue, relatively higher insulin sensitivity, and better β-cell function, compared with those in the MUO group; but there were no significant differences in sex hormones (except for free T and sex hormone-binding globulin) and ultrasound manifestations between MHO and MUO women. Conclusion(s) For the first time, our findings suggest that MetS does not add additional risk for PCOS. In addition, we found that both MUO and MHO are associated with insulin resistance to some extent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|