Investigation of the association between mitochondrial DNA and p53 gene mutations in transitional cell carcinoma of the bladder
| Autor: | Elif Cigdem Kaspar, Levent Türkeri, Tuba Avcilar, Deniz Kirac, Zehra Kaya, Korkut Ulucan, Ahmet Ilter Güney, Gulsah Koc, Deniz Ergec |
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| Přispěvatelé: | Avcilar, Tuba, Kirac, Deniz, Ergec, Deniz, Koc, Gulsah, Ulucan, Korkut, Kaya, Zehra, Kaspar, Elif Cigdem, Turkeri, Levent, Guney, Ahmet Ilter |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
bladder carcinoma p53 Cancer Research Mitochondrial DNA medicine.medical_treatment Biology Gene mutation medicine.disease_cause Cystectomy 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Mutation Bladder cancer mtDNA medicine.disease Molecular biology CANCER TCC 030104 developmental biology Transitional cell carcinoma Oncology 030220 oncology & carcinogenesis Cancer research Carcinogenesis URINARY-BLADDER |
| Popis: | Bladder carcinoma is the most common malignancy of the urinary tract. The major aim of the present study is to investigate the association between mitochondrial DNA (mtDNA) and p53 gene mutations in bladder carcinoma. A total of 30 patients with transitional cell carcinoma and 27 controls were recruited for the study. Bladder cancer tissues were obtained by radical cystectomy or transurethral resection. Genomic DNA was extracted from peripheral blood. mtDNA and p53 genes were amplified by polymerase chain reaction and sequenced directly. A total of 37 polymorphisms were identified, among which, 2 mutations were significant in the patient group, and 1 mutation was significant in the control group. Additionally, 5 different moderate positive correlations between mtDNA mutations and 3 different positive correlations between p53 gene and mtDNA mutations were detected. The high incidence of mtDNA and p53 gene mutations in bladder cancer suggests that these genes could be important in carcinogenesis. |
| Databáze: | OpenAIRE |
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