Fungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women
| Autor: | Claudine Piérard-Franchimont, Gérald Pierard, Grégory Szepetiuk, Devillers C, Pascale Quatresooz |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
beta-Glucans Hyperkeratosis Chitin Placebo Gastroenterology law.invention Double-Blind Method Randomized controlled trial law Internal medicine Diabetes mellitus medicine Stratum corneum Humans Pharmacology (medical) Skin Glucan Foot Dermatoses Pharmacology chemistry.chemical_classification Corneocyte Emollients business.industry Water Galvanic Skin Response General Medicine Middle Aged medicine.disease Water Loss Insensible Surgery Menopause Diabetes Mellitus Type 1 Treatment Outcome medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Female business |
| Zdroj: | Expert Opinion on Pharmacotherapy. 10:2221-2229 |
| ISSN: | 1744-7666 1465-6566 |
| Popis: | Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women.To compare the effects of a 2.5% chitin-glucan formulation with its placebo, and commercially available glycerol formulations.This two-step controlled double-blind, randomized, intra-individual study was performed in 30 type 1 and 2 diabetic menopausal women suffering from xerosis of the feet. The formulations were applied once daily for 3 weeks. Electrometric assessments were performed on three sites of the feet at entry in the study, at weekly intervals during the treatment phase, and in a 2-week follow-up out of treatment. Positive controls consisted in two commercially available formulations enriched in glycerol.Data revealed an unequivocal benefit provided by the 2.5% chitin-glucan formulation compared with placebo. The electrometric values were significantly higher at each evaluation time during both treatment and follow-up phases. The two glycerol-enriched formulations showed slightly different kinetics of SC moisturization. A steep increase was followed by a plateau level and a rapid decline after stopping the treatments.The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles. |
| Databáze: | OpenAIRE |
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