Absolute cerebral blood flow: Assessment with a novel low-radiation-dose dynamic CT perfusion technique in a swine model
| Autor: | Yixiao Zhao, Sabee Molloi, Brooklynn Flynn, Pablo Abbona, Shant Malkasian, Logan Hubbard |
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| Rok vydání: | 2022 |
| Předmět: |
Swine
Clinical Sciences Contrast Media Perfusion scanning Bioengineering Article Multidetector computed tomography Fluorescent microspheres Models Low dose ct Medicine Animals Humans Radiology Nuclear Medicine and imaging Bolus tracking Tomography screening and diagnosis Radiological and Ultrasound Technology business.industry Animal Angiography Myocardial Perfusion Imaging Neurosciences Brain Repeatability X-Ray Computed 4.1 Discovery and preclinical testing of markers and technologies Perfusion Stroke Detection Nuclear Medicine & Medical Imaging Cerebral blood flow Cerebrovascular Circulation Biomedical Imaging Neurology (clinical) Dynamic ct Tomography X-Ray Computed Nuclear medicine business |
| Zdroj: | Journal of neuroradiology = Journal de neuroradiologie, vol 49, iss 2 J Neuroradiol |
| Popis: | Rationale and objectivesTo validate the accuracy of a novel low-dose dynamic CT perfusion technique in a swine model using fluorescent microsphere measurement as the reference standard.Materials and methodsContrast-enhanced dynamic CT perfusion was performed in five swine at baseline and following brain embolization. Reference microspheres andintravenous contrast (370mg/ml iodine, 1ml/kg)were injected (5ml/s), followed by dynamic CT perfusion. Scan parameters were 320×0.5mm, 100 kVp and 200mA. On average, 47 contrast-enhanced volume scans were acquired per acquisition to capture the time attenuation curve. For each acquisition, only two systematically selected volume scans were used to quantify brain perfusion withfirst-pass analysis technique. The first volume scan was selected at the base, simulating bolus tracking, while the second volumeat the peak of the time attenuation curve similar to a CT angiogram. Regional low-dose CT perfusion measurements were compared to the microsphere perfusion measurements with t-test, linear regression and Bland-Altman analysis. The radiation dose of the two-volume CT perfusion technique was determined.ResultsLow-dose CT perfusion measurements (PCT) showed excellent correlation with reference microsphere perfusion measurements (PMICRO) by PCT= 1.15 PMICRO- 0.01 (r=0.93, p≤0.01). The CT dose index and dose-length product for the two-volume CT perfusion technique were 25.6 mGy and 409.6 mGy, respectively.ConclusionsThe accuracy and repeatability of a low-dose dynamic CT perfusion technique was validated in a swine model. This technique has the potential for accurate diagnosis and follow up of stroke and vasospasm. |
| Databáze: | OpenAIRE |
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