Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity
| Autor: | Yukiko Matsuo, Kazuhiro Takatori, Yoshihiro Mimaki, Haruhiko Fukaya, Emi Yamaguchi, Ryo Hakamata, Kanae Ootomo |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Stereochemistry Plant Science Horticulture Plant Roots 01 natural sciences Biochemistry Hydrolysis chemistry.chemical_compound Furanocoumarin Coumarins Benzofuran Molecular Biology Angelica Benzofurans biology 010405 organic chemistry Angelica dahurica General Medicine biology.organism_classification Coumarin 0104 chemical sciences PPAR gamma chemistry Phytochemical Solvolysis Two-dimensional nuclear magnetic resonance spectroscopy 010606 plant biology & botany |
| Zdroj: | Phytochemistry. 173:112301 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2020.112301 |
| Popis: | A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica root. The structures of a total of twelve undescribed compounds were determined by extensive spectroscopic analysis, including 2D NMR data, hydrolysis, and solvolysis, followed by either physicochemical and spectroscopic data or X-ray crystallographic analysis. The isolated compounds were evaluated for their PPAR-γ ligand-binding activity, and six compounds showed significant PPAR-γ ligand-binding activity. In particular, the undescribed benzofuran derivative, 3-[6,7-furano-9-hydroxy-4-(2″,3″-dihydroxy-3″-methylbutyloxy)]-phenyl propionic acid, exhibited the most potent PPAR-γ ligand-binding activity and accumulated intracellular lipid in 3T3-L1 cells. |
| Databáze: | OpenAIRE |
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