Concentration of serotonin in blood platelets: effect of reserpine in migraineurs
| Autor: | J. A. P. Jensen, F. Fog‐Møller, T. Dalsgaard‐Nielsen, I. Kemp Genefke, B. Bryndum |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Serotonin Reserpine Migraine Disorders Internal medicine medicine Humans Platelet In patient Vascular headache business.industry Histocytochemistry medicine.disease Endocrinology Spectrometry Fluorescence Neurology Anesthesia Female Neurology (clinical) business medicine.drug |
| Zdroj: | Headache. 15(2) |
| ISSN: | 0017-8748 |
| Popis: | SYNOPSIS Twenty-three migraineurs and 7 controls were given intramuscular injections of reserpine. Platelets 5-HT(serotonin) was measured 4–6 hours after injection and in migraineurs at weekly intervals for six weeks. Platelet 5-HT fell to comparable levels in migraineurs and controls but 20 migraineurs had vascular headache within six hours after reserpine injection. No control had vascular headache after reserpine administration. Decreased platelet 5-HT levels were found for 4–6 weeks after injection of reserpine. During the period of low 5-HT levels there was a decreased frequency and intensity of migrainous attach in patients. |
| Databáze: | OpenAIRE |
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