Treatment of severe verapamil poisoning with combined amrinone-isoproterenol therapy
| Autor: | Jacques Bonte, Martin Goenen, Jacques Col, Antoine Compere |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Inotrope medicine.medical_specialty Adolescent medicine.medical_treatment chemistry.chemical_element Calcium Amrinone Internal medicine Isoprenaline medicine Humans Chemotherapy business.industry Isoproterenol Conductible Verapamil chemistry cardiovascular system Cardiology Milrinone Drug Therapy Combination Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American Journal of Cardiology. 58:1142-1143 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(86)90143-8 |
| Popis: | Verapamil is a slow channel calcium entry blocker that exerts its pharmacologic effects by blocking calcium influx in arterial smooth muscle as well in conductible and contractile myocardial cells; it depresses sinus node function and the atrioventricular conduction system and causes arterial vasodilation. Overdose of verapamil has been reported 1,2 and usually responds to standard treatment, including calcium, catecholamines and ventricular pacing. We report a case of severe verapamil poisoning that did not respond to this therapy, but to a combination of amrinone and isoproterenol. Our therapeutic conception was based on experimental data that show that amrinone or milrinone, an amrinone-like compound, reversed the negative effects of verapamil on sinus node and atrioventricular conduction and its negative inotropic action. 3,4 |
| Databáze: | OpenAIRE |
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