Prognostic value of the Epstein–Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma

Autor: Ying Liu, Hongwei Sun, Junjie Liu, Boqing Li, Pengzhou Gai, Zhenyu Zhang, Xiaofei Ji, Xiuzhi Zhou
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Epstein-Barr Virus Infections
Herpesvirus 4
Human
Mutation rate
tumor suppressor gene p53
Gene mutation
medicine.disease_cause
Epstein–Barr virus
Exon
0302 clinical medicine
Recurrence
Risk Factors
Medicine
In Situ Hybridization
General Medicine
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunohistochemistry
Tumor Burden
Gene Expression Regulation
Neoplastic
Oncology
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Female
Disease Susceptibility
Adult
Tumor suppressor gene
lcsh:RC254-282
Virus
nasopharyngeal squamous cell carcinoma
03 medical and health sciences
Cell Line
Tumor
Biomarkers
Tumor
Humans
Radiology
Nuclear Medicine and imaging
Gene
Aged
gene mutations
business.industry
Nasopharyngeal Neoplasms
medicine.disease
030104 developmental biology
Nasopharyngeal carcinoma
protein expressions
Mutation
Cancer research
prognosis
Neoplasm Grading
Tumor Suppressor Protein p53
business
Zdroj: Journal of Cancer Research and Therapeutics, Vol 15, Iss 2, Pp 426-436 (2019)
ISSN: 1998-4138
0973-1482
Popis: Aims and Methods: Retrospectively, this paper compared the differences of the Epstein–Barr virus (EBV)-encoded small RNAs (EBERs), protein expression and gene mutations of tumor suppressor gene p53 (TP53) in keratinized nasopharyngeal squamous cell carcinoma (KNSCC) and nonKNSCC, and the relationships between pathological features and the prognosis of patients were analyzed. Results: The positive rate of EBERs hybridization and TP53 expressions was 76.3% and 52.2%, respectively, while the mutation rate of TP53 gene was 39.6%. Logistic regression analysis showed direct relationships between the subtypes of nasopharyngeal squamous cell carcinoma (NPSCC) and EBERs-positive, or frequent consumption of pickled food. Overall survival rates of patients with positive TP53 expression, the TP53 gene mutations, vascular invasions, organ metastases, lymph node metastasis, and clinical recurrence were significantly lower than those of patients without those symptoms. The poorer prognosis was related to regularly drinking and the advanced age. According to the Cox regression analysis, we found that the main prognostic factors of NPSCC patients were the aging, recurrence, TP53 gene mutations, especially exon 7 or 8 mutations. Conclusions: We concluded that there were the correlations between NPSCC subtypes with EBV infection and frequent intaking of pickled food, while aging, clinical recurrence, and TP53 gene mutations were independent predictors for the poor prognosis of nasopharyngeal carcinoma.
Databáze: OpenAIRE
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