Rivaroxaban for the prevention of outcomes in patients with atrial fibrillation in clinical practice: an indirect comparison of national and international registries
| Autor: | Francisco Marin, Marcelo Sanmartín Fernández, Iñaki Lekuona, Fernando Arribas, Gonzalo Barón-Esquivias, Vivencio Barrios, Juan Cosin-Sales, Román Freixa-Pamias, Jaime Masjuan, Alejandro I Pérez-Cabeza, Vanessa Roldán Schilling, José Manuel Vázquez Rodríguez, Carles Rafols Priu, Manuel Anguita Sánchez |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Comparative Effectiveness Research. 11:1173-1184 |
| ISSN: | 2042-6313 2042-6305 |
| Popis: | Objective: To analyze the effectiveness and safety of rivaroxaban in patients with atrial fibrillation (AF). Methods: The clinical profile and outcomes of the EMIR study were indirectly compared with those of ROCKET-AF, eight other Spanish observational studies and XANTUS. Results: In EMIR, mean age was 74.2 years and CHA 2 DS 2 -VASc was 3.5. In the rivaroxaban arm of the ROCKET-AF trial, mean age was 73 years and CHADS 2 was 3.5, whereas in the Spanish studies mean age ranged from 74.9 years to 78.4 years and CHA 2 DS 2 -VASc from 3.5 to 4.3. In EMIR, rates of stroke/systemic embolism, major adverse cardiovascular events, cardiovascular death and major bleeding were 0.57, 1.07, 0.63 and 1.04 events/100 patient-years, respectively. In ROCKET-AF, these numbers were 1.7, 3.91, 1.53 and 3.6 events/100 patient-years, respectively. In the Spanish studies, rates of stroke and major bleeding were 0–1.8 and 0.22–4.2 events/100 patient-years, respectively. In XANTUS, rates of stroke, major adverse cardiovascular events and major bleeding were 0.7, 1.8 and 2.1 events/100 patient-years, respectively. Conclusion: Despite the fact that rivaroxaban is prescribed for elderly patients with a high thromboembolic risk, rates of outcomes remain low. |
| Databáze: | OpenAIRE |
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