Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

Autor: María Andrea Previtali, Pablo Teta, Yosena Chiani, Agustina A. Ojeda, Tamara Ricardo, Norma Bibiana Vanasco, Paula Cornejo, María Fernanda Schmeling, Paulina Jacob
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Bacterial Diseases
Male
0301 basic medicine
Serotype
Veterinary medicine
Rodent
Physiology
RC955-962
Akodon azarae
Pathology and Laboratory Medicine
Kidney
Biochemistry
Rodent Diseases
0302 clinical medicine
Flooding
Seroepidemiologic Studies
Zoonoses
Immune Physiology
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Enzyme-Linked Immunoassays
Mammals
Leptospira
Immune System Proteins
Ecology
biology
Eukaryota
Antibodies
Bacterial
Leptospirosis
Bacterial Pathogens
Infectious Diseases
Medical Microbiology
Vertebrates
Epidemiological Monitoring
Female
Pathogens
Public aspects of medicine
RA1-1270
Research Article
Neglected Tropical Diseases
Environmental Monitoring
Ecological Metrics
Immunology
030231 tropical medicine
Argentina
Enzyme-Linked Immunosorbent Assay
Rodentia
Research and Analysis Methods
Rodents
Microbiology
Antibodies
03 medical and health sciences
biology.animal
medicine
Animals
Seroprevalence
Immunoassays
Microbial Pathogens
Oligoryzomys
Bacteria
Ecology and Environmental Sciences
Organisms
Public Health
Environmental and Occupational Health
Biology and Life Sciences
Proteins
Species Diversity
Tropical Diseases
biology.organism_classification
medicine.disease
Rats
030104 developmental biology
Amniotes
Immunologic Techniques
Earth Sciences
Hydrology
Zdroj: PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008222 (2020)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
1935-2727
Popis: Background Leptospirosis is a zoonotic disease that can be transmitted by contact with the urine of infected mammals. Rodents play a mayor role in the transmission of leptospires to humans. The province of Santa Fe reports the greatest number of cases in Argentina. Yet, in this region, there are still knowledge gaps regarding the diversity of rodent species that may be hosts of pathogenic leptospires. The aims of this study were to evaluate the presence of leptospiral antibodies in rodents from three riverside communities of Santa Fe, and to identify factors associated with leptospiral infection. Methodology/Principal findings Each community was divided into three environmental settings based on the level of human disturbance, and sampled during two springs (Sep-Oct 2014 and 2015) and one autumn (Mar-Apr 2015). Serum samples of captured sigmodontine and murine rodents were tested for leptospiral antibodies by enzyme-linked immunosorbent assay (ELISA), and microagglutination test (MAT) was used to assess the infecting serovar in seropositive individuals. Factors influencing seropositivity were analyzed using logistic regression models. We caught 119 rodents, of which 101 serums were suitable for analysis. Most frequently trapped species were Scapteromys aquaticus, Akodon azarae and Oligoryzomys spp., with seroprevalences of 41.3%, 42.9% and 55% respectively. Seropositivity was higher in individuals with an average body condition score and in those that were sexually mature, but in the latter the differences were marginally significant. Conclusions/Significance Our results suggest that native rodents may be playing a role in the environmental circulation of pathogenic leptospires and provide relevant information for public health policies in the area.
Author summary Rodents are considered as the main reservoirs of pathogenic leptospires, which can cause leptospirosis, a disease that can be severe for both humans and domestic animals. Multiple socio-environmental factors have been found to influence the risk of leptospirosis, and many mammal species can play a role in the transmission of the bacteria. The purpose of this study was to investigate the local conditions and rodent fauna that may influence the risk of leptospirosis in communities located in the floodplains of the Parana river, near Santa Fe, Argentina. We conducted a survey of antibodies against leptospires in rodents from the center, border, and outside of three riverside settlements. We observed a relatively high seroprevalence among captured individuals (42%). Animals with an intermediate body condition were more likely to be seropositive. In most sites, native rodents were dominant over introduced rats and mice and lived close to human dwellings. Given the socio-environmental conditions observed in these settlements and the high frequency of floods that affect them, the presence of potentially infected rodents provide ample opportunities for leptospirosis to affect these communities.
Databáze: OpenAIRE
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