Risks of Coaggregation of Major Psychiatric Disorders Among First-Degree Relatives of Patients With Bipolar I and Bipolar II Disorder
| Autor: | Ya Mei Bai, Wen Han Chang, Tzeng Ji Chen, Tung Ping Su, Mu Hong Chen, Chih-Ming Cheng, Cheng Ta Li, Shih-Jen Tsai, Chia-Fen Tsai |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Risk Proband medicine.medical_specialty Bipolar Disorder Bipolar I disorder Taiwan Bipolar II disorder medicine Humans Family Bipolar disorder First-degree relatives Psychiatry Depressive Disorder Major business.industry Mental Disorders Family aggregation medicine.disease Psychiatry and Mental health Schizophrenia Relative risk Female business |
| Zdroj: | The Journal of Clinical Psychiatry. 82 |
| ISSN: | 1555-2101 |
| Popis: | Background: Etiologic differences between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) have been challenged recently, and family epidemiologic studies may elucidate the matter. Nevertheless, it remains unclear whether BD-I and BD-II display different familial aggregation patterns within each bipolar disorder subtype and coaggregation with other psychiatric disorders. Method: Per the Taiwan National Health Insurance Research Database (N = 23,258,175), patients with bipolar disorder were classified as having BD-I or BD-II based on the history of psychiatric hospitalization for a manic episode. During the study period (2001-2011), 184,958 first-degree relatives (FDRs) of patients with BD-I and BD-II were identified. By comparing patients with 1:4 age-, sex-, and kinship-matched samples without BD-I/BD-II probands, the relative risks (RRs) of major psychiatric disorders were estimated. Results: FDRs of BD-I probands had a significantly higher risk of BD-I than those of BD-II probands (BD-I proband: RR = 15.80 vs BD-II proband: RR = 5.68, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|