Ontogenetic profile of glutamate uptake in brain structures slices from rats: sensitivity to guanosine
| Autor: | Emílio Hideyuki Moriguchi, Susana Tchernin Wofchuk, Juliana Moura Rodrigues, Marcos Emilio dos Santos Frizzo, Graça Fabiana Ramos dos Santos Godinho, Fábio Duarte Schwalm, Diogo O. Souza, Ana Paula Thomazi |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Aging Excitotoxicity Hippocampus Guanosine Striatum Biology In Vitro Techniques medicine.disease_cause chemistry.chemical_compound Glutamates Internal medicine Cortex (anatomy) medicine Animals Rats Wistar Glutamate receptor Brain Rats medicine.anatomical_structure Endocrinology chemistry Biochemistry Metabotropic glutamate receptor NMDA receptor Developmental Biology |
| Zdroj: | Mechanisms of ageing and development. 125(7) |
| ISSN: | 0047-6374 |
| Popis: | The excitotoxicity of the neurotransmitter glutamate has been shown to be connected with many acute and chronic diseases of the CNS. High affinity sodium-dependent glutamate transporters play a key role in maintaining adequate levels of extracellular glutamate. In the present study, we used slices of striatum, hippocampus and cortex from rat brain to describe the in vitro profile of glutamate uptake during development and ageing, and its sensitivity to guanosine. In all structures, glutamate uptake was higher in immature animals. There was a maximum decrease in glutamate uptake in striatum and hippocampus in 15-month-old rats, which later increased, while in cortex there was a significant decrease in rats aged 60 days old. The effect of guanosine seems to be age and structure dependent since the increase in basal glutamate uptake was only seen in slices of cortex from 10-day-old animals. |
| Databáze: | OpenAIRE |
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