Effects of olmesartan on arterial stiffness in rats with chronic renal failure

Autor: Kwang-Ming Fang, Ming-Shiou Wu, Yi-Kai Su, Yao-Chen Chuang
Rok vydání: 2012
Předmět:
Glycation End Products
Advanced
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Renal function
Hemodynamics
Tetrazoles
Nephrectomy
Antioxidants
Blood Urea Nitrogen
chemistry.chemical_compound
Vascular Stiffness
Internal medicine
medicine.artery
Malondialdehyde
medicine
Chronic renal failure
Animals
Rats
Wistar
Advanced glycation end products
Aorta
Aortic impedance analysis
Original Investigation
Creatinine
business.industry
Diabetes
Mean Aortic Pressure
Imidazoles
medicine.disease
Angiotensin II
Rats
Disease Models
Animal
Oxidative Stress
chemistry
lcsh:RC666-701
Arterial stiffness
Cardiology
Kidney Failure
Chronic
Hypertrophy
Left Ventricular
business
Olmesartan
Cardiology and Cardiovascular Medicine
Reactive Oxygen Species
Angiotensin II Type 1 Receptor Blockers
medicine.drug
Zdroj: Cardiovascular Diabetology
Cardiovascular Diabetology, Vol 11, Iss 1, p 66 (2012)
ISSN: 1475-2840
Popis: Background It has been suggested that the antioxidant properties of olmesartan (OLM), an angiotensin II type 1 receptor (AT1R) blocker, contribute to renal protection rather than blood pressure lowering effects despite the fact that causal relationships between hypertension and renal artery disease exist. This study aimed to examine the hypothesis whether the antioxidative activities of OLM were correlated to arterial stiffness, reactive oxygen species and advanced glycation end products (AGEs) formation in rats with chronic renal failure (CRF). Methods CRF rats were induced by 5/6 nephrectomy and randomly assigned to an OLM (10 mg/day) group or a control group. Hemodynamic states, oxidative stress, renal function and AGEs were measured after 8 weeks of OLM treatment. Results All the hemodynamic derangements associated with renal and cardiovascular dysfunctions were abrogated in CRF rats receiving OLM. Decreased cardiac output was normalized compared to control (p p p p p p p Conclusion OLM treatment could ameliorate arterial stiffness in CRF rats with concomitant inhibition of MDA and AGEs levels through the reduction of oxidative stress in aortic wall.
Databáze: OpenAIRE
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