The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na+, K+)-, Mg2+-ATPase activities, antioxidant status, and learning performance of aged rats
| Autor: | Stylianos Tsakiris, Chrissoula I Liakou, Ioanna Messari, Haris Carageorgiou, Antonios C. Sideris |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Antioxidant
Neuropsychiatric Disease and Treatment Aché medicine.medical_treatment Neurosciences. Biological psychiatry. Neuropsychiatry Pharmacology chemistry.chemical_compound medicine RC346-429 Biological Psychiatry Cholinesterase Rivastigmine biology business.industry Selegiline Acetylcholinesterase language.human_language Psychiatry and Mental health Mg2+-ATPase chemistry language biology.protein Neurology. Diseases of the nervous system business Aged rat medicine.drug RC321-571 |
| Zdroj: | Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 4, Pp 687-699 (2008) |
| ISSN: | 1178-2021 1176-6328 |
| Popis: | Haris Carageorgiou1, Antonios C Sideris1, Ioanna Messari1, Chrissoula I Liakou1, Stylianos Tsakiris21Department of Pharmacology, 2Department of Physiology, Medical School, University of Athens, Athens, GreeceAbstract: We investigated the effects of rivastigmine (a cholinesterase inhibitor) and selegiline ((-)deprenyl, an irreversible inhibitor of monoamineoxidase-B), alone and in combination, on brain acetylcholinesterase (AChE), (Na+, K+)-, Mg2+-ATPase activities, total antioxidant status (TAS), and learning performance, after long-term drug administration in aged male rats. The possible relationship between the biochemical and behavioral parameters was evaluated.Methods: Aged rats were treated (for 36 days) with rivastigmine (0.3 mg/kg rat/day ip), selegiline (0.25 mg/kg rat/day im), rivastigmine plus selegiline in the same doses and way of administration as separately. Aged and adult control groups received NaCl 0.9% 0.5 ml ip.Results: TAS was lower in aged than in adult rats, rivastigmine alone does not affect TAS, decreases AChE activity, increases (Na+, K+)-ATPase and Mg2+-ATPase activity of aged rat brain and improves cognitive performance. Selegiline alone decreases free radical production and increases AChE activity and (Na+, K+)-ATPase activity, improving cognitive performance as well. In the combination: rivastigmine seems to cancel selegiline action on TAS and AChE activity, while it has additive effect on (Na+, K+)-ATPase activity. In the case of Mg2+-ATPase selegiline appears to attenuate rivastigmine activity. No statistically significant difference was observed in the cognitive performance.Conclusion: Reduced TAS, AChE activity and learning performance was observed in old rats. Both rivastigmine and selesiline alone improved performance, although they influenced the biochemical parameters in a different way. The combination of the two drugs did not affect learning performance.Keywords: aged rat, brain enzymes, TAS, learning, rivastigmine, selegiline |
| Databáze: | OpenAIRE |
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