Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
| Autor: | Ken-ichi Isobe, Natsuko Uekawa, Akihiko Nishikimi, Nahum Meller, Mitsuo Maruyama, Martin A. Schwartz |
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| Rok vydání: | 2005 |
| Předmět: |
DOCK10
Subfamily Dock180 DOCK11 Molecular Sequence Data Biophysics GTPase Biology Biochemistry Cell Line Substrate Specificity Mice Rho Structural Biology Dock10 Dock11 Genetics Animals Guanine Nucleotide Exchange Factors Protein Isoforms Amino Acid Sequence Lymphocytes GEF CZH2 Cloning Molecular cdc42 GTP-Binding Protein Molecular Biology Gene Expression Profiling Germinal center Cell Biology DOCK9 Molecular biology Protein Structure Tertiary rac GTP-Binding Proteins Enzyme Activation Dock9 Guanine nucleotide exchange factor Sequence Alignment Protein Binding |
| Zdroj: | FEBS Letters. 579:1039-1046 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2005.01.006 |
| Popis: | A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a screen for genes enriched in germinal center B cells. Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42-related proteins TC10 or TCL. Their tissue distributions are distinct, however, with zizimin2 expressed predominantly in lymphocytes and an opposite pattern for zizimin1. Zizimin3 was also analyzed and showed distinct GTPase specificity and tissue distribution. |
| Databáze: | OpenAIRE |
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