Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis
| Autor: | Katlego Sojane, Martyn A. French, Saleha Omarjee, Bernadett I Gosnell, Keshni Hiramen, Thumbi Ndung'u, Christina C. Chang, Sharon R Lewin, Richard T. Kangethe, Mohamed-Yunus S Moosa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030106 microbiology Cryptococcus CCL3 cerebrospinal fluid HIV 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid cryptococcal meningitis Immune reconstitution inflammatory syndrome Acquired immunodeficiency syndrome (AIDS) medicine 030212 general & internal medicine Prospective cohort study CSF albumin biology business.industry Brief Report RNA biology.organism_classification medicine.disease Virology 3. Good health Infectious Diseases Oncology business |
| Zdroj: | Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofx032 |
| Popis: | We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log10 copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4+ T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome. |
| Databáze: | OpenAIRE |
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