Simultaneous Whole-Body Time-of-Flight 18F-FDG PET/MRI
| Autor: | Craig S. Levin, Greg Zaharchuk, Mehran Jamali, Andrew Quon, Andrei Iagaru, Sanjiv S. Gambhir, Garry E. Gold, Shreyas S. Vasanawala, Erik Mittra, Ryogo Minamimoto, Robert J. Herfkens |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pilot Projects Multimodal Imaging Article 18f fdg pet Fluorodeoxyglucose F18 Humans Medicine Whole Body Imaging Radiology Nuclear Medicine and imaging Aged Aged 80 and over PET-CT business.industry Reproducibility of Results General Medicine Middle Aged Magnetic Resonance Imaging First generation Clinical Practice Positron-Emission Tomography Female Radiopharmaceuticals Mr images Tomography X-Ray Computed Whole body Nuclear medicine business |
| Zdroj: | Clinical Nuclear Medicine. 40:1-8 |
| ISSN: | 0363-9762 |
| Popis: | The recent introduction of hybrid PET/MRI scanners in clinical practice has shown promising initial results for several clinical scenarios. However, the first generation of combined PET/MRI lacks time-of-flight (TOF) technology. Here we report the results of the first patients to be scanned on a completely novel fully integrated PET/MRI scanner with TOF.We analyzed data from patients who underwent a clinically indicated F FDG PET/CT, followed by PET/MRI. Maximum standardized uptake values (SUVmax) were measured from F FDG PET/MRI and F FDG PET/CT for lesions, cerebellum, salivary glands, lungs, aortic arch, liver, spleen, skeletal muscle, and fat. Two experienced radiologists independently reviewed the MR data for image quality.Thirty-six patients (19 men, 17 women, mean [±standard deviation] age of 61 ± 14 years [range: 27-86 years]) with a total of 69 discrete lesions met the inclusion criteria. PET/CT images were acquired at a mean (±standard deviation) of 74 ± 14 minutes (range: 49-100 minutes) after injection of 10 ± 1 mCi (range: 8-12 mCi) of F FDG. PET/MRI scans started at 161 ± 29 minutes (range: 117 - 286 minutes) after the F FDG injection. All lesions identified on PET from PET/CT were also seen on PET from PET/MRI. The mean SUVmax values were higher from PET/MRI than PET/CT for all lesions. No degradation of MR image quality was observed.The data obtained so far using this investigational PET/MR system have shown that the TOF PET system is capable of excellent performance during simultaneous PET/MR with routine pulse sequences. MR imaging was not compromised. Comparison of the PET images from PET/CT and PET/MRI show no loss of image quality for the latter. These results support further investigation of this novel fully integrated TOF PET/MRI instrument. |
| Databáze: | OpenAIRE |
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