Air pollution and retained particles in the lung
Autor: | Sverre Vedal, Bonnie Stevens, Carmen Avila-Casado, Teresa I. Fortoul, Andrew Churg, Michael Brauer |
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Rok vydání: | 2001 |
Předmět: |
Health
Toxicology and Mutagenesis Air pollution Mineralogy medicine.disease_cause Ultrafine particle medicine Humans Tissue Distribution Cities Particle Size Lung Aged Air Pollutants Chemistry Public Health Environmental and Occupational Health Environmental Exposure Environmental exposure Middle Aged Particulates medicine.anatomical_structure Environmental chemistry Particle Female Autopsy Particle size Geometric mean Research Article |
Zdroj: | Environmental Health Perspectives Scopus-Elsevier |
ISSN: | 1552-9924 0091-6765 |
Popis: | Epidemiologic evidence associates particulate air pollution with cardiopulmonary morbidity and mortality. The biological mechanisms underlying these associations and the relationship between ambient levels and retained particles in the lung remain uncertain. We examined the parenchymal particle content of 11 autopsy lungs from never-smoking female residents of Mexico City, a region with high ambient particle levels [3-year mean PM(10) (particulate matter < or = 10 microm in aerodynamic diameter)= 66 microg/m(3)], and 11 control residents of Vancouver, British Columbia, Canada, a region with relatively low levels (3-year mean PM(10) = 14 microg/m(3). Autopsy lungs were dissolved in bleach and particles were identified and counted by analytical electron microscopy. Total particle concentrations in the Mexico City lungs were significantly higher [geometric mean = 2,055 (geometric SD = 3.9) x 10(6) particles/g dry lung vs. 279 (1.8) x 10(6) particles/g dry lung] than in lungs from Vancouver residents. Lungs from Mexico City contained numerous chain-aggregated masses of ultrafine carbonaceous spheres, some of which contained sulfur, and aggregates of ultrafine aluminum silicate. These aggregates made up an average of 25% of the total particles by count in the lungs from Mexico City, but were only rarely seen in lungs from Vancouver. These observations indicate for the first time that residence in a region with high levels of ambient particles results in pulmonary retention of large quantities of fine and ultrafine particle aggregates, some of which appear to be combustion products. |
Databáze: | OpenAIRE |
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