Construction of a Tubular Scaffold that Mimics J-Shaped Stress/Strain Mechanics Using an Innovative Electrospinning Technique
| Autor: | Jeff Fish, Deepak Jain, Richard G. Payne, Christopher W. Genheimer, Jonathon Campbell, Harry Scott Rapoport, Joydeep Basu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Toughness Materials science Polyurethanes Biomedical Engineering Medicine (miscellaneous) Bioengineering Stress (mechanics) Tensile Strength Materials Testing Ultimate tensile strength Electrochemistry Pressure Animals Humans Elasticity (economics) Composite material Tissue Engineering Tissue Scaffolds biology Stress–strain curve Soft tissue Equipment Design Elasticity Electrospinning biology.protein Female Stress Mechanical Elastin Polyglycolic Acid |
| Zdroj: | Tissue Engineering Part C: Methods. 18:567-574 |
| ISSN: | 1937-3392 1937-3384 |
| DOI: | 10.1089/ten.tec.2011.0286 |
| Popis: | Soft tissues such as blood vessel, lung, ureter, skin, etc., possess mechanical behavior characterized by a "J"-shaped curve on a stress-strain diagram with a low-stiffness highly elastic zone giving rise to a high-stiffness zone. This mechanical behavior may be adaptive and protective against aneurysm formation in tissues whose primary loading is pressure-based. "J"-shaped behavior arises from the synergistic interplay of two main structural proteins: collagen and elastin. An innovative electrospinning technique has been utilized to form tubular scaffold composites with structural features reminiscent of the corrugated laminae seen in blood vessels. In doing so, tubular scaffolds have been fabricated with complex "J"-shaped behavior through the use of elastic polyurethane and reinforcing poly-glycolic acid (PGA) woven mesh. In these studies, corrugated laminae were formed on the 175 μm and 1.5 mm scale. Initial moduli were 0.5±0.17 MPa (mean±standard deviation) giving rise to stiffer moduli of 36.09±6.72 MPa at a strain of 1.31±0.15. Burst pressures were physiologically relevant at 3095±1016 mmHg. The toughness of these prototypes was 6.3±1.9 MJ/m(3). The ability to employ different materials and different formation parameters utilizing this technique promises the ability to match complex stress-strain behaviors in soft tissues with a high degree of fidelity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|