Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering
| Autor: | Kevin Richard Sitek, Shanqing eCai, Deryk Scott Beal, Joseph S Perkell, Frank eGuenther, Satrajit S Ghosh |
|---|---|
| Přispěvatelé: | Institute for Medical Engineering and Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, McGovern Institute for Brain Research at MIT, Sitek, Kevin R., Cai, Shanqing, Beal, Deryk S., Perkell, Joseph S., Ghosh, Satrajit S. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Speech production
Cerebellum Stuttering Thalamus 050105 experimental psychology lcsh:RC321-571 White matter 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine persistent developmental stuttering medicine structural connectivity resting state functional connectivity diffusion weighted imaging (DWI) 0501 psychology and cognitive sciences lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry resting state Biological Psychiatry Original Research Resting state fMRI Functional connectivity diffusion 05 social sciences nervous system diseases Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology connectivity Orbitofrontal cortex medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery MRI Cognitive psychology |
| Zdroj: | Frontiers Frontiers in Human Neuroscience Frontiers in Human Neuroscience, Vol 10 (2016) |
| Popis: | Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex (OFC). Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and OFC may underlie successful compensatory mechanisms by more fluent stutterers. National Institutes of Health (U.S.) (NIH grant R01-DC007683) National Institutes of Health (U.S.) (NIH grant R56-DC0010849) National Institutes of Health (U.S.) (NIH grant T32- DC000038) |
| Databáze: | OpenAIRE |
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