The Quinpirole Hypolocomotive Effects are Strain and Route of Administration Dependent in SHR and SLA16 Isogenic Rats
| Autor: | Renata Cristina Nunes Marchette, Juliana Cavalli, Maria Elisa Corvino, Renata Aparecida Nedel Pértile, Geison S. Izídio, André Ramos, E. Pavesi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Agonist Elevated plus maze Quinpirole medicine.drug_class Dopamine Anxiety Motor Activity Pharmacology Hippocampus Rats Mutant Strains Open field 03 medical and health sciences 0302 clinical medicine Rats Inbred SHR Dopamine receptor D2 Genetics Haloperidol medicine Animals Receptor Genetics (clinical) Ecology Evolution Behavior and Systematics Behavior Animal Receptors Dopamine D2 Chemistry Drug Administration Routes Dopaminergic Rats Dopamine D2 Receptor Antagonists 030104 developmental biology Locomotion 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavior Genetics. 47:552-563 |
| ISSN: | 1573-3297 0001-8244 |
| Popis: | The SHR and SLA16 inbred strains present behavioral differences in anxiety/emotionality that could be under the influence of dopaminergic neurotransmission. In order to investigate the role of D2 receptors in modulating such differences, an agonist (quinpirole) and an antagonist (haloperidol) of this receptor were administered, either via systemic injection (IP), or microinjected into the ventral area of the hippocampus (vHIP). Quinpirole and haloperidol IP decreased locomotor activity, only in SLA16 rats in the open-field (OF), and in both strains in the elevated plus-maze (EPM). Quinpirole also increased the preference for the aversive areas of the EPM. Quinpirole vHIP decreased locomotor activity in both strains. Haloperidol vHIP did not elicit behavioural changes and no differences in the levels of D2 receptors and of dopamine transporter in the hippocampus were found. Results indicate that systemic activation/blocking of D2 receptors caused a strain-dependent hypolocomotion, whereas activation of D2 receptors in the vHIP, but not D2 receptor antagonism, regardless of dose, decreased general locomotor activity in the two strains. Therefore, we suggest that genomic differences in the chromosome 4 can influence the locomotor activity regulated by the D2 dopaminergic receptor, especially in the vHIP. |
| Databáze: | OpenAIRE |
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