Sonochemical synthesis and fabrication of perovskite type calcium titanate interfacial nanostructure supported on graphene oxide sheets as a highly efficient electrocatalyst for electrochemical detection of chemotherapeutic drug
| Autor: | Shen-Ming Chen, Veerappan Mani, Umamaheswari Rajaji, Tse-Wei Chen, A. Irudaya Jothi, Yi Chen Huang, Tien-Wen Tseng |
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| Rok vydání: | 2019 |
| Předmět: |
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Molecular Materials science Acoustics and Ultrasonics Antineoplastic Agents Hormonal Oxide Nanoparticle 02 engineering and technology Chemistry Techniques Synthetic 010402 general chemistry Electrocatalyst 01 natural sciences Catalysis law.invention Inorganic Chemistry chemistry.chemical_compound law Chemical Engineering (miscellaneous) Environmental Chemistry Humans Radiology Nuclear Medicine and imaging Ultrasonics Perovskite (structure) Titanium Nanocomposite Molecular Structure Graphene Organic Chemistry Electrochemical Techniques 021001 nanoscience & nanotechnology Flutamide 0104 chemical sciences Nanostructures Calcium titanate chemistry Chemical engineering Electrode Calcium Graphite 0210 nano-technology |
| Zdroj: | Ultrasonics sonochemistry. 69 |
| ISSN: | 1873-2828 |
| Popis: | In green approaches for electrocatalyst synthesis, sonochemical methods play a powerful role in delivering the abundant surface areas and nano-crystalline properties that are advantageous to electrocatalytic detection. In this article, we proposed the sphere-like and perovskite type of bimetal oxides which are synthesized through an uncomplicated sonochemical procedure. As a yield, the novel calcium titanate (orthorhombic nature) nanoparticles (CaTiO3 NPs) decorated graphene oxide sheets (GOS) were obtained through simple ultrasonic irradiation by a high-intensity ultrasonic probe (Titanium horn; 50 kHz and 60 W). The GOS/CaTiO3 NC were characterized morphologically and chemically through the analytical methods (SEM, XRD, and EDS). Besides, as-prepared nanocomposites were modified on a GCE (glassy carbon electrode) and applied towards electrocatalytic and electrochemical sensing of chemotherapeutic drug flutamide (FD). Notably, FD is a crucial anticancer drug and also a non-steroidal anti-androgen chemical. Mainly, the designed and modified sensor has shown a wide linear range (0.015–1184 µM). A limit of detection was calculated as nanomolar level (5.7 nM) and sensitivity of the electrode is 1.073 μA μM−1 cm−2. The GOS/CaTiO3 modified electrodes have been tested in human blood and urine samples towards anticancer drug detection. |
| Databáze: | OpenAIRE |
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