Colonic Cell Proliferation in Normal Mucosa of Patients with Colon Cancer
| Autor: | Valentino Giachè, Christopher S Potten, Paola Faraoni, Giorgia Donata Zappoli Thyrion, E. Tisti, Manuela Balzi, Luca Bandettini, Aldo Becciolini |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Pathology medicine.medical_specialty Mitotic index Colorectal cancer Cell Crypt Cell Count Labelling Mitotic Index medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Intestinal Mucosa Aged Aged 80 and over Goblet cell business.industry Cell growth Hematology General Medicine Middle Aged medicine.disease medicine.anatomical_structure Oncology Colonic Neoplasms Regression Analysis Female business Cell Division |
| Zdroj: | Acta Oncologica. 37:65-71 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.1080/028418698423195 |
| Popis: | Cell kinetics parameters have been analysed in colonic mucosa at different distances from a tumour in patients with colon carcinoma. Total cell number (TCN), 3H thymidine labelling index (TLI), mitotic index (MI), Goblet cell index (GCI) and the distribution of labelled cells along the crypt column (cell position frequency plot) were determined in well-aligned crypts. Total cell number, GCI and the labelled cell position frequency plots were similar in different samples from the same individual. A negative linear correlation between TCN and TLI was observed. The analysis of the cell position plots showed two patterns 1) with a high concentration in the bottom fifth of the crypt and 2) with frequent labelled cells at high positions. Whereas a negative correlation between overall TLI and the percent contribution to the TLI of the lowermost fifth was seen, the correlation was positive for the next 3 fifths and labelling was absent in the last part of the crypt. |
| Databáze: | OpenAIRE |
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