Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens
| Autor: | Jide Tian, Lorraine Hanssen, Yuxin Lu, Hoa Dang, Daniel L. Kaufman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
T-Lymphocytes
animal diseases T cell Freund's Adjuvant Immunology Antigen-Presenting Cells chemical and pharmacologic phenomena Biology Mice Immune system Antigen medicine Animals IL-2 receptor Antigens Antigen-presenting cell Mice Inbred BALB C Effector Th1 Cells biochemical phenomena metabolism and nutrition Acquired immune system Mice Inbred C57BL B-1 cell medicine.anatomical_structure bacteria Immunologic Memory |
| Zdroj: | Cellular Immunology. 224:74-85 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2003.08.007 |
| Popis: | Memory and effector T cells modulate subsequently primed T cell responses to the same antigen. However, little is known about the impact of pre-existing memory and effector T cell immunity on subsequently primed immune responses to unrelated antigens. Here, we show that an antigen-primed first wave of Th1 and Th2 immunity enhanced or inhibited the subsequently primed T cell immunity to an unrelated antigen, depending on whether the second antigen was administered in the same or opposite type of adjuvant. The regulatory effects of the first wave of T cell immunity on the subsequent T cell responses to an unrelated antigen attenuated over time. Notably, following challenge with the second antigen, there was a mutual cross-regulation between the first and second wave of humoral responses to unrelated antigens. Thus, immunization with one antigen not only primes immune responses to that antigen, but also influences subsequently primed immune responses to unrelated antigens. |
| Databáze: | OpenAIRE |
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