Mixture and concentration effects on odorant receptor response patterns in vivo
| Autor: | Timothy S. McClintock, Patrick Breheny, William B. Titlow, Tomoko Sengoku, Qiang Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Physiology Chemistry musculoskeletal neural and ocular physiology Sensory system Sensory Systems Sensory neuroscience Cell biology 03 medical and health sciences Behavioral Neuroscience 030104 developmental biology 0302 clinical medicine Single species Odor In vivo Physiology (medical) Odorant Receptor Receptor psychological phenomena and processes 030217 neurology & neurosurgery G protein-coupled receptor |
| Zdroj: | Chemical senses. |
| ISSN: | 1464-3553 |
| Popis: | Natural odors are mixtures of volatile chemicals (odorants). Odors are encoded as responses of distinct subsets of the hundreds of odorant receptors and trace amine-associated receptors expressed monogenically by olfactory sensory neurons. This is an elegantly simple mechanism for differentially encoding odors but it is susceptible to complex dose–response relationships and interactions between odorants at receptors, which may help explain olfactory phenomena, such as mixture suppression, synthetic versus elemental odor processing, and poorly predictable perceptual outcomes of new odor mixtures. In this study, in vivo tests in freely behaving mice confirm evidence of a characteristic receptor response pattern consisting of a few receptors with strong responses and a greater number of weakly responding receptors. Odorant receptors responsive to an odor are often unrelated and widely divergent in sequence, even when the odor consists of a single species of odorant. Odorant receptor response patterns to a citrus odor broaden with concentration. Some highly sensitive receptors respond only to a low concentration but others respond in proportion to concentration, a feature that may be critical for concentration-invariant perception. Other tests find evidence of interactions between odorants in vivo. All of the odorant receptor responses to a moderate concentration of the fecal malodor indole are suppressed by a high concentration of the floral odorant, α-ionone. Such suppressive effects are consistent with prior evidence that odorant interactions at individual odorant receptors are common. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|