New Poly(3-hydroxybutyrate) Microparticles with Paclitaxel Sustained Release for Intraperitoneal Administration
| Autor: | V. L. Myshkina, Anton P. Bonartsev, S. G. Yakovlev, Natalia V. Andronova, T.K. Mahina, A.L. Zernov, Galina B. Smirnova, Mikhail S. Kalishjan, I. I. Zharkova, Juliya A. Borisova, Helena M. Treshalina, Konstantin V. Shaitan, Garina A. Bonartseva |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Cancer Research Paclitaxel Biocompatibility Surface Properties Polyesters media_common.quotation_subject Hydroxybutyrates Antineoplastic Agents Breast Neoplasms 02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Carcinoma Lewis Lung Mice Structure-Activity Relationship chemistry.chemical_compound In vivo Prohibitins Tumor Cells Cultured medicine Animals Humans Particle Size Cell Proliferation media_common Dose-Response Relationship Drug Molecular Structure Chemistry Cell growth Mammary Neoplasms Experimental Lewis lung carcinoma Cancer 021001 nanoscience & nanotechnology medicine.disease In vitro 0104 chemical sciences Molecular Medicine Drug Screening Assays Antitumor 0210 nano-technology Injections Intraperitoneal |
| Zdroj: | Anti-Cancer Agents in Medicinal Chemistry. 17:434-441 |
| ISSN: | 1871-5206 |
| DOI: | 10.2174/1871520615666160504095433 |
| Popis: | Background: Poly(hydroxyalkanoates) (PHA) have recently attracted increasing attention due to their biodegradability and high biocompatibility, which makes them suitable for the development of new prolong drug formulations. Objective: This study was conducted to develop new prolong paclitaxel (PTX) formulation based on poly(3- hydroxybutyrate) (PHB) microparticles. Method: PHB microparticles loaded with antitumor cytostatic drug PTX were obtained by spray-drying method using Nano Spray Dryer B-90. The PTX release kinetics in vitro from PHB microparticles and their cytotoxity on murine hepatoma cell line MH-22a were studied. Microparticles antitumor activity in vivo was studied using intraperitoneally (i.p.) transplanted tumor models: murine Lewis lung carcinoma and xenografts of human breast cancer RMG1. Results: Uniform PTX release from PHB-microparticles during 2 months was observed. PTX-loaded PHB microparticles have demonstrated a significant antitumor activity versus pure drug both in vitro in murine hepatoma cells and in vivo when administered i.p. to mice with murine Lewis lung carcinoma and xenografts of human breast cancer RMG1. Conclusion: The developed technique of PTX sustained delivery from PHB-microparticles has therapeutic potential as prolong anticancer drug formulation. |
| Databáze: | OpenAIRE |
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