Bisphosphonate-functionalized micelles for targeted delivery of curcumin to metastatic bone cancer
| Autor: | Sumedh Kamble, Markus Müllner, Théophile Pelras, Ramin Rohanizadeh, Pegah Varamini |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Curcumin
Polymers medicine.medical_treatment Pharmaceutical Science Antineoplastic Agents Bone Neoplasms Poloxamer 02 engineering and technology 030226 pharmacology & pharmacy Micelle Metastatic bone cancer 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Tumor Microenvironment medicine In patient Particle Size Micelles Drug Carriers Alendronate Diphosphonates Bone cancer business.industry technology industry and agriculture General Medicine Bisphosphonate 021001 nanoscience & nanotechnology medicine.disease Advanced cancer Drug Liberation Durapatite chemistry Cancer research Nanoparticles 0210 nano-technology business |
| Zdroj: | Pharmaceutical Development and Technology. 25:1118-1126 |
| ISSN: | 1097-9867 1083-7450 |
| Popis: | Metastatic (secondary) bone cancer is one of the major causes of death in patients with advanced cancer. A lack of options for the targeted delivery of a desired therapeutic payload to multiple tumour modules located in the bone is still one of the foremost hurdles in the treatment/prevention of metastatic bone cancer. Curcumin has a proven anticancer potential with known challenges for application as a pharmaceutical agent. We have previously shown that micellar formulations could overcome some of these challenges and enhances its anti-cancer activity. In this study, we have developed a targeted drug delivery system using bisphosphonate (alendronate) conjugated Pluronic F127 micelles that could efficiently target, and specifically deliver curcumin to the osteolytic tumour microenvironment in the bone. Characterization of the formulation of curcumin-encapsulated alendronate-conjugated micelles demonstrated that the micelles have nanoscale size (∼27 nm) with a positive surface charge (+2.87 mV) and 4% drug loading. The alendronate-conjugated micelles showed significant bone-targeting potential. Rapid binding of the micelles to hydroxyapatite surface suggested that these nanoparticles are promising carriers for effective and targeted delivery of curcumin to osteolytic tumours in the bone. |
| Databáze: | OpenAIRE |
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