Change in vascular smooth muscle response to 5-HT due to short- or long-term endothelial denudation of the bovine digital vein
| Autor: | Jean-Claude Desfontis, Mohamed Yassine Mallem, Simona Punzi, Marc Gogny, Chiara Belloli |
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| Rok vydání: | 2016 |
| Předmět: |
Hoof and Claw
Serotonin medicine.medical_specialty RHOA Vascular smooth muscle Endothelium 030204 cardiovascular system & hematology Muscle Smooth Vascular Veins Nitric oxide Foot Diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Inflammation General Veterinary biology Vasomotor Chemistry Superoxide Fasudil medicine.disease Endocrinology medicine.anatomical_structure Immunology cardiovascular system biology.protein Cattle Animal Science and Zoology Endothelium Vascular Reperfusion injury 030217 neurology & neurosurgery Muscle Contraction |
| Zdroj: | The Veterinary Journal. 207:154-159 |
| ISSN: | 1090-0233 |
| Popis: | Several chronic progressive vascular diseases, such as laminitis, show vasocontractile dysfunction that might evolve into reperfusion injury and/or vessel structural remodelling, which may be traced back to aberrant endothelial function. In the present study, the vasomotor responses of bovine digital veins (BDVs) to 5-hydroxytryptamine (5-HT) were investigated in blood vessels, with and without endothelium present, and in samples deprived of endothelium before or after overnight incubation in tissue culture medium, to evaluate the effects of short- and long-term endothelial damage on vascular smooth muscle (VSM) reactivity. No significant effects were observed in the blood vessels tested immediately after the removal of endothelium. In contrast, a significant increase in VSM reactivity to 5-HT was seen in vessels incubated without endothelium. This long-term change in smooth muscle reactivity was prevented by exposure to the nitric oxide (NO) donor nitroprusside (P |
| Databáze: | OpenAIRE |
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