Prognostic value of neutrophil-to-lymphocyte ratio in advanced nasopharyngeal carcinoma: a large institution-based cohort study from an endemic area
| Autor: | Feng-Ting Zhu, Guan-Qun Zhou, Si-Yang Wang, Zi-Bin Liang, Jun Dong, Wayne R. Lawrence, Shao-Yi Chen, Fan Zhang, Ying Sun, Ji-Jin Yao, Le-Wei Yang, Wangjian Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research medicine.medical_specialty Multivariate analysis Adolescent Neutrophils lcsh:RC254-282 Gastroenterology Cohort Studies Leukocyte Count 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine Genetics medicine Humans Clinical significance Lymphocytes Neutrophil to lymphocyte ratio Neutrophil-to-lymphocyte ratio Aged Nasopharyngeal Carcinoma Proportional hazards model business.industry fungi Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis medicine.disease Nasopharyngeal carcinoma advanced 030104 developmental biology Oncology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Cohort Female business Research Article Cohort study |
| Zdroj: | BMC Cancer BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019) |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-018-5236-2 |
| Popis: | Background Findings remain unclear whether neutrophil-to-lymphocyte ratio (NLR) detrimentally affects advanced nasopharyngeal carcinoma (NPC) prognosis. We aim to evaluate the prognostic value of NLR in patients with NPC based on a large-scale cohort from an endemic area. Methods We selected patients retrospectively from a cohort examining long-term cancer outcomes following diagnosis. Neutrophil counts and lymphocyte counts were assessed prior to treatment. Kaplan–Meier method and log-rank test were used to calculate and compare survival outcomes. Additionally, Cox proportional hazards model was utilized to carry out univariate and multivariate analyses. Results Between October 2009 and August 2012, we enrolled 1550 consecutive NPC patients staged II-IVB. The median value of NLR was 2.27 (interquartile range [IQR], 1.71–3.12). Determined by operating characteristic curve using overall survival (OS) as an endpoint, the cutoff value for NLR was 2.50. At 5 years, NLR > 2.50 was associated with inferior OS (90.3% vs 82.5%; P |
| Databáze: | OpenAIRE |
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