A systematic study of the dissolution and relative bioavailability of four ginsenosides in the form of ultrafine granular powder, common powder and traditional pieces of Panax quinquefolius L, in vitro and in beagles
| Autor: | An Liu, Cai-Xia Wang, Sha Chen, Junqiu Liu, Jin-le Cheng, Jun Zhang, Li-hua Peng, Hao-qi Xu |
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| Rok vydání: | 2016 |
| Předmět: |
Absorption (pharmacology)
Ginsenosides Biological Availability Panax 01 natural sciences Dogs Pharmacokinetics Oral administration Drug Discovery Animals American ginseng Dissolution Pharmacology Chromatography Molecular Structure Traditional medicine biology Plant Extracts 010405 organic chemistry Chemistry 010401 analytical chemistry Half-life biology.organism_classification 0104 chemical sciences Bioavailability Drug Liberation Area Under Curve Powders Quantitative analysis (chemistry) Half-Life |
| Zdroj: | Journal of Ethnopharmacology. 185:9-16 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2016.03.032 |
| Popis: | Ethnopharmacological relevance Panax quinquefolius L (PQ), also known as American ginseng, has been used as a medicinal herb for thousands of years in the Far East, which was wildly used actively in healing the cardiovascular, endocrine and immune systems, in supporting chemoprevention of cancer. Materials and methods An integrated, rapid, sensitive and reliable UHPLC-ESI-QQQ MS/MS method was validated and successfully applied in a pharmacokinetics study in which four representative ginsenosides were measured in beagle plasma following oral administration of Panax quinquefolius L (PQ) in the form of ultrafine granular powder, standard powder and an extract. Results Two paired ions ([M+Na] + in the positive MS process, and two characteristic ions [Q 3 ] + in the positive MS/MS process) of the target compounds were optimized and selected for improved qualitative and quantitative analysis of ginsenosides in beagle plasma. The relative bioavailability of the target ginsenosides in these three formulations was measured by the pharmacokinetic parameters, including C max , T max , AUC 0−∞ and so on. The ultrafine granular powder had the highest bioavailability, as well as the greatest extent of and fastest dissolution in vitro . Conclusion Our results show that improved formulations of PQ could facilitate the dissolution and promote absorption of the important compounds it contains. |
| Databáze: | OpenAIRE |
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