Sustained Myocarditis following Messenger RNA Vaccination against Coronavirus Disease 2019: Relation to Neutralizing Antibody and Amelioration by Low-Dose Booster Vaccination

Autor: Koji Miyazaki, Toshiharu Fujii, Kikue Mori, Ryuichi Tamimoto, Hirofumi Nagamatsu, Tsutomu Murakami, Yasunori Cho, Shinya Goto, Hidezo Mori
Rok vydání: 2023
Předmět:
Zdroj: Journal of Clinical Medicine
Volume 12
Issue 4
Pages: 1421
ISSN: 2077-0383
DOI: 10.3390/jcm12041421
Popis: We recently reported that sub-acute myocarditis occurred following the initial two doses of messenger RNA-based vaccination against coronavirus disease 2019 (0.3 mL Comirnaty®) in elderly Japanese patients with cardiac dysfunction. The present retrospective study of 76 patients revealed that myocarditis following the initial doses persisted for 12 months, was associated with low levels of neutralizing antibodies, and was ameliorated by reducing the third vaccine dose. Low neutralizing antibody levels (
Databáze: OpenAIRE
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