Cohort-profile: Household transmission of SARS-CoV-2 in a low-resource community in Rio de Janeiro, Brazil
| Autor: | Patrícia Brasil, Luana Damasceno, Trevon Fuller, Leonardo S Bastos, Oswaldo G Cruz, Fernando Medeiros, Guilherme Amaral Calvet, Paola Resende, Jimmy Whitworth, Chris Smith, Marilda M Siqueira, Marilia Carvalho |
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| Rok vydání: | 2023 |
| Předmět: |
Adult
Male Epidemiology Clinical Sciences Antibodies Vaccine Related Clinical Research Biodefense Humans Prospective Studies Child Pandemics Lung Other Medical and Health Sciences SARS-CoV-2 Prevention Community child health COVID-19 General Medicine Infectious Diseases Emerging Infectious Diseases Good Health and Well Being Public Health and Health Services Female Immunization Infection Brazil Biotechnology |
| Zdroj: | BMJ open, vol 12, iss 12 |
| ISSN: | 2044-6055 |
| Popis: | PurposeTo better understand the household transmission of SARS-COV-2 in a low-resource community in Rio de Janeiro during the COVID-19 pandemic (2020–2022).ParticipantsThis is an open prospective cohort study of children ≤12 years old and their household contacts. During home visits over 24 months, we collected data on sociodemographic characteristics, behavioural data, clinical manifestations of SARS-CoV-2, vaccination status, SARS-CoV-2 (reverse transcription-polymerase chain reaction) RT-PCR and anti-S antibody tests. Among adults, the majority of participants were women (62%).Findings to dateWe enrolled 845 families from May 2020 to May 2022. The median number of residents per household was four. The median household density, defined as the number of persons per room, was 0.95. The risk of SARS-CoV-2 occurrence was higher in households with a high number of persons per room. Children were not the principal source of SARS-CoV-2 infections in their households during the first wave of the pandemic.Future plansFuture studies will investigate cellular and humoral immune responses to locally circulating SARS-CoV-2 variants, which is relevant for the design of vaccines, antivirals and monoclonal antibodies. We will also engage in outreach to encourage vaccination as a means of limiting the transmission of novel SARS-CoV-2 variants and other emerging pathogens. |
| Databáze: | OpenAIRE |
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