Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients

Autor: Angela K. Birnbaum, Jeannine M. Conway, Ilo E. Leppik, Janice B. Schwartz, Sai Praneeth Reddy Bathena, Ghada F. Ahmed, Richard C. Brundage
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Aging
saturable absorption
Cyclohexanecarboxylic Acids
gabapentin
Pharmaceutical Science
Pharmacology
Neurodegenerative
030226 pharmacology & pharmacy
Epilepsy
0302 clinical medicine
Models
80 and over
Homes for the Aged
Tissue Distribution
Pharmacology & Pharmacy
Prospective Studies
Amines
gamma-Aminobutyric Acid
Volume of distribution
Aged
80 and over

Analgesics
Chronic pain
Pharmacology and Pharmaceutical Sciences
Middle Aged
nursing home
Anticonvulsants
Female
Drug
Gabapentin
medicine.drug
Glomerular Filtration Rate
medicine.medical_specialty
Renal function
Biological Availability
elderly patients
Models
Biological

Article
Dose-Response Relationship
03 medical and health sciences
Pharmacokinetics
Clinical Research
Internal medicine
medicine
Humans
Aged
Dose-Response Relationship
Drug

business.industry
medicine.disease
Biological
Comorbidity
Bioavailability
Nursing Homes
Nonlinear Dynamics
business
030217 neurology & neurosurgery
Zdroj: AAPS J
The AAPS journal, vol 19, iss 2
Popis: Pharmacokinetic data of gabapentin (GBP) in community-dwelling elderly patients show a significant effect of advanced age on GBP pharmacokinetics due to altered renal function. However, there are no data in elderly nursing home (NH) patients to evaluate gabapentin absorption and elimination. Our objective was to characterize the pharmacokinetics of GBP in elderly nursing home patients maintained on GBP therapy. This was a prospective pharmacokinetic study in elderly nursing home patients (≥60years) receiving GBP for the management of chronic pain or epilepsy from seven nursing homes. Pharmacokinetic parameters were estimated by nonlinear mixed-effects modeling. A one-compartment model described the data and clearance (CL) was associated with estimated glomerular filtration rate (eGFR) (p
Databáze: OpenAIRE
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