Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus
Autor: | Leon N. Davis, Isabel C. Gonzalez, Charles K. Smith |
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Rok vydání: | 2004 |
Předmět: |
Nitrile
Stereochemistry Clinical Biochemistry Pharmaceutical Science Thiophenes Biochemistry Chemical synthesis Pyrrole derivatives Structure-Activity Relationship chemistry.chemical_compound In vivo Drug Discovery medicine Animals Organic chemistry Anthelmintic Molecular Biology Anthelmintics Molecular Structure biology Chemistry Organic Chemistry Biological activity General Medicine biology.organism_classification Thiophene derivatives In vitro Kinetics Molecular Medicine Haemonchus Haemonchus contortus medicine.drug |
Zdroj: | Bioorganic & Medicinal Chemistry Letters. 14:4037-4043 |
ISSN: | 0960-894X |
Popis: | A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3-carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus. |
Databáze: | OpenAIRE |
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