Combining antioxidant hydrogels with self-assembled microparticles for multifunctional wound dressings
| Autor: | Florida Voli, Arianna Tavanti, Annafranca Farfalla, Manuela Curcio, Elvira Pantuso, Giuseppe Cirillo, Francesca Iemma, Maria Eugenia Butini, Orazio Vittorio, Fiore Pasquale Nicoletta, Antonella Leggio, Emanuele Valli, M. Di Luca |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Biocompatibility
Chemistry Radical polymerization technology industry and agriculture Biomedical Engineering Plasticizer 02 engineering and technology General Chemistry General Medicine Polyethylene glycol Polyethylene 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Chemical engineering Stearate Self-healing hydrogels General Materials Science Microparticle 0210 nano-technology |
| Popis: | A multi-functional composite to be employed as a dressing material was prepared by combining hydrogel and microparticle systems. For the synthesis of the hydrogel counterpart, a free radical polymerization was carried out using a gelatin–curcumin conjugate, previously obtained through immobilized laccase catalysis, and polyethylene glycol dimethacrylate as a functional element, plasticizer, and crosslinker. The hydrogel was found to possess high water affinity, biocompatibility, and the ability to reduce the H2O2-induced oxidative stress on MRC-5 cells by 30%. The spherical microparticle system (mean diameter of 1.75 μm) was prepared by self-assembly of a keratin-methacrylated polyethylene glycol-40 stearate derivative synthesized by a free radical reaction. The final composite, prepared by absorption of microparticles on the hydrogel system, was found to be effective as a support for enhanced cell growth (3.5 times). Furthermore, a reduction of methicillin-resistant Staphylococcus aureus proliferation by 1 log10 CFU was reached taking advantage of the sustained release of the antimicrobial quercetin. |
| Databáze: | OpenAIRE |
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