Sleep loss and structural plasticity
| Autor: | Simon C. Warby, Valérie Mongrain, Cassandra C. Areal |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nervous system Synapse 03 medical and health sciences 0302 clinical medicine Neuroplasticity medicine Animals Wakefulness Neurons Neuronal Plasticity General Neuroscience Sleep in non-human animals Sleep deprivation 030104 developmental biology medicine.anatomical_structure Structural plasticity Synapses Sleep Deprivation medicine.symptom Psychology Sleep Neuroscience 030217 neurology & neurosurgery Sleep loss |
| Zdroj: | Current opinion in neurobiology. 44 |
| ISSN: | 1873-6882 |
| Popis: | Wakefulness and sleep are dynamic states during which brain functioning is modified and shaped. Sleep loss is detrimental to many brain functions and results in structural changes localized at synapses in the nervous system. In this review, we present and discuss some of the latest observations of structural changes following sleep loss in some vertebrates and insects. We also emphasize that these changes are region-specific and cell type-specific and that, most importantly, these structural modifications have functional roles in sleep regulation and brain functions. Selected mechanisms driving structural modifications occurring with sleep loss are also discussed. Overall, recent research highlights that extending wakefulness impacts synapse number and shape, which in turn regulate sleep need and sleep-dependent learning/memory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect