Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer
| Autor: | Marianne Taylor, C. Jay Engel, Walter Kocha, Barbara Fisher, Glenn Bauman, Francisco Perera, E.A Plewes, Larry Stitt, Mark Vincent, Gregory M.M Videtic |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty Colorectal cancer medicine.medical_treatment Rectum Adenocarcinoma Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Infusions Intravenous Aged Aged 80 and over Radiation Rectal Neoplasms business.industry Abdominoperineal resection Wound dehiscence Radiotherapy Dosage Middle Aged medicine.disease Combined Modality Therapy Surgery Radiation therapy Regimen medicine.anatomical_structure Oncology Female Fluorouracil business Chemoradiotherapy |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 42:319-324 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(98)00214-4 |
| Popis: | Background and Purpose: To determine the percentage of complete responders and the resectability rate for patients with locally advanced carcinoma of the rectum treated by 5-fluorouracil (5-FU) infusional chemotherapy and pelvic radiation. Materials and Methods: Between October 1992 and June 1996, 29 patients with a diagnosis of locally advanced unresectable rectal cancer received preoperative 5 FU by continuous intravenous infusion at a dose of 225 mg/m 2 /day concurrent with pelvic radiation (median 54 Gy/28 fractions). All patients were clinical stage T4 on the bases of organ invasion or tumor fixation. Median time for surgical resection was 6 weeks. Results: Median follow-up for the group was 28 months (range 5–57 months). Six patients were felt to be persistently unresectable or developed distant metastases and did not undergo surgical resection. Of the 29 patients, 23 proceeded to surgery, 18 were resectable for cure, 13 by abdominoperineal resection, 3 by anterior resection and 2 by local excision. Of the 29 patients, 4 (13%) had a complete response, and 90% were clinically downstaged. Of the 18 resected patients, 1 has died of his disease, 17 are alive, and 15 disease-free. The regimen was well tolerated; there was only one treatment-related complication, a wound dehiscence. Conclusion: The combination of 5 FU infusion and pelvic radiation in the management of locally advanced rectal cancer is well tolerated and provides a baseline for comparison purposes with future combinations of newer systemic agents and radiation. |
| Databáze: | OpenAIRE |
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