Establishment of Enzyme Immunoassay for Measuring Serum Sultopride Levels
| Autor: | Saburo Takahashi, Hiroo Ishii, Tatsuyuki Muratake, Toshiyuki Someya, Tetsuya Yashiki, Noriyuki Sunahara, Hiroyuki Funaoka, Etsuko Nakajima, Akiko Shirai, Kazutaka Shimoda |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pharmacology chemistry.chemical_classification Reproducibility Chromatography medicine.diagnostic_test Middle Aged Dilution Immunoenzyme Techniques chemistry.chemical_compound Enzyme chemistry Sultopride Immunoassay medicine Humans Female Pharmacology (medical) Amisulpride Sulpiride Quantitative analysis (chemistry) Chromatography High Pressure Liquid Aged Antipsychotic Agents |
| Zdroj: | Therapeutic Drug Monitoring. 23:277-281 |
| ISSN: | 0163-4356 |
| Popis: | Measurement of serum sultopride levels was performed using an enzyme immunoassay. Little or no cross-reactivity with metabolites of sultopride and other drugs was found. The results of reproducibility, recovery, and dilution testing were all good enough for clinical use. A comparison between the measurement values of this method (y) with that of high-performance liquid chromatography (x) showed high correlation (n = 211, r = 0.991, p < 0.0001, y = 0.99x + 107.5). In a comparison between the sultopride dose and serum levels in 161 patients, interindividual differences were large (19 times for same doses), implying that the serum level cannot be predicted from the dosage. The method was found to be reliable for serum level measurements of sultopride and useful for monitoring compliance and assessing the optimal dose. |
| Databáze: | OpenAIRE |
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