Dark Side of Cytotoxic Therapy: Chemoradiation-Induced Cell Death and Tumor Repopulation
| Autor: | Juan-juan Dai, Dian-na Gu, Ling Tian, Qian Huang, Ming-jie Jiang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Programmed cell death Cell Survival Antineoplastic Agents Metastasis 03 medical and health sciences Adenosine Triphosphate 0302 clinical medicine Cell Line Tumor Neoplasms Tumor Microenvironment medicine Humans Cytotoxic Therapy Cellular Senescence Cell Proliferation Tumor microenvironment Cell Death Cell growth business.industry Chemoradiotherapy medicine.disease Cancer treatment 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research Tumor Escape Repopulation business Signal Transduction |
| Zdroj: | Trends in Cancer. 6:419-431 |
| ISSN: | 2405-8033 |
| DOI: | 10.1016/j.trecan.2020.01.018 |
| Popis: | Accelerated tumor repopulation following chemoradiation is often observed in the clinic, but the underlying mechanisms remain unclear. In recent years, dying cells caused by chemoradiation have attracted much attention, and they may manifest diverse forms of cell death and release complex factors and thus orchestrate tumor repopulation cascades. Dying cells potentiate the survival of residual living tumor cells, remodel the tumor microenvironment, boost cell proliferation, and accelerate cancer cell metastasis. Moreover, dying cells also mediate the side effects of chemoradiation. These findings suggest more caution when weighing the benefits of cytotoxic therapy and the need to accordingly develop new strategies for cancer treatment. |
| Databáze: | OpenAIRE |
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